Showing posts with label Article. Show all posts
Showing posts with label Article. Show all posts

Hiroshima Bombing: 6 August 1945




THE ATOMIC BOMBING OF HIROSHIMA
Hiroshima (August 6, 1945)


In the early morning hours of August 6, 1945, a B-29 bomber named Enola Gay took off from the island of Tinian and headed north by northwest toward Japan. The bomber's primary target was the city of Hiroshima, located on the deltas of southwestern Honshu Island facing the Inland Sea. Hiroshima had a civilian population of almost 300,000 and was an important military center, containing about 43,000 soldiers.

The bomber, piloted by the commander of the 509th Composite Group, Colonel Paul Tibbets, flew at low altitude on automatic pilot before climbing to 31,000 feet as it neared the target area. At approximately 8:15 a.m. Hiroshima time the Enola Gay released "Little Boy," its 9,700-pound uranium bomb, over the city. Tibbets immediately dove away to avoid the anticipated shock wave. Forty-three seconds later, a huge explosion lit the morning sky as Little Boy detonated 1,900 feet above the city, directly over a parade field where soldiers of the Japanese Second Army were doing calisthenics. Though already eleven and a half miles away, the Enola Gay was rocked by the blast. At first, Tibbets thought he was taking flak. After a second shock wave (reflected from the ground) hit the plane, the crew looked back at Hiroshima. "The city was hidden by that awful cloud . . . boiling up, mushrooming, terrible and incredibly tall," Tibbets recalled. The yield of the explosion was later estimated at 15 kilotons (the equivalent of 15,000 tons of TNT).

On the ground moments before the blast it was a calm and sunny Monday morning. An air raid alert from earlier that morning had been called off after only a solitary aircraft was seen (the weather plane), and by 8:15 the city was alive with activity -- soldiers doing their morning calisthenics, commuters on foot or on bicycles, groups of women and children working outside to clear firebreaks. Those closest to the explosion died instantly, their bodies turned to black char. Nearby birds burst into flames in mid-air, and dry, combustible materials such as paper instantly ignited as far away as 6,400 feet from ground zero. The white light acted as a giant flashbulb, burning the dark patterns of clothing onto skin (right) and the shadows of bodies onto walls. Survivors outdoors close to the blast generally describe a literally blinding light combined with a sudden and overwhelming wave of heat. (The effects of radiation are usually not immediately apparent.) The blast wave followed almost instantly for those close-in, often knocking them from their feet. Those that were indoors were usually spared the flash burns, but flying glass from broken windows filled most rooms, and all but the very strongest structures collapsed. One boy was blown through the windows of his house and across the street as the house collapsed behind him. Within minutes 9 out of 10 people half a mile or less from ground zero were dead.

People farther from the point of detonation experienced first the flash and heat, followed seconds later by a deafening boom and the blast wave. Nearly every structure within one mile of ground zero was destroyed, and almost every building within three miles was damaged. Less than 10 percent of the buildings in the city survived without any damage, and the blast wave shattered glass in suburbs twelve miles away. The most common first reaction of those that were indoors even miles from ground zero was that their building had just suffered a direct hit by a bomb. Small ad hoc rescue parties soon began to operate, but roughly half of the city's population was dead or injured. In those areas most seriously affected virtually no one escaped serious injury. The numerous small fires that erupted simultaneously all around the city soon merged into one large firestorm, creating extremely strong winds that blew towards the center of the fire. The firestorm eventually engulfed 4.4 square miles of the city, killing anyone who had not escaped in the first minutes after the attack. One postwar study of the victims of Hiroshima found that less than 4.5 percent of survivors suffered leg fractures. Such injuries were not uncommon; it was just that most who could not walk were engulfed by the firestorm.

Even after the flames had subsided, relief from the outside was slow in coming. For hours after the attack the Japanese government did not even know for sure what had happened. Radio and telegraph communications with Hiroshima had suddenly ended at 8:16 a.m., and vague reports of some sort of large explosion had begun to filter in, but the Japanese high command knew that no large-scale air raid had taken place over the city and that there were no large stores of explosives there. Eventually a Japanese staff officer was dispatched by plane to survey the city from overhead, and while he was still nearly 100 miles away from the city he began to report on a huge cloud of smoke that hung over it. The first confirmation of exactly what had happened came only sixteen hours later with the announcement of the bombing by the United States. Relief workers from outside the city eventually began to arrive and the situation stabilized somewhat. Power in undamaged areas of the city was even restored on August 7th, with limited rail service resuming the following day. Several days after the blast, however, medical staff began to recognize the first symptoms of radiation sickness among the survivors. Soon the death rate actually began to climb again as patients who had appeared to be recovering began suffering from this strange new illness. Deaths from radiation sickness did not peak until three to four weeks after the attacks and did not taper off until seven to eight weeks after the attack. Long-range health dangers associated with radiation exposure, such as an increased danger of cancer, would linger for the rest of the victims' lives, as would the psychological effects of the attack.

No one will ever know for certain how many died as a result of the attack on Hiroshima. Some 70,000 people probably died as a result of initial blast, heat, and radiation effects. This included about twenty American airmen being held as prisoners in the city. By the end of 1945, because of the lingering effects of radioactive fallout and other after effects, the Hiroshima death toll was probably over 100,000. The five-year death total may have reached or even exceeded 200,000, as cancer and other long-term effects took hold.

At 11:00 a.m., August 6 (Washington D.C. time), radio stations began playing a prepared statement from President Truman (right) informing the American public that the United States had dropped an entirely new type of bomb on the Japanese city of Hiroshima -- an "atomic bomb." Truman warned that if Japan still refused to surrender unconditionally, as demanded by the Potsdam Declaration of July 26, the United States would attack additional targets with equally devastating results. Two days later, on August 8, the Soviet Union declared war on Japan and attacked Japanese forces in Manchuria, ending American hopes that the war would end before Russian entry into the Pacific theater. By August 9th, American aircraft were showering leaflets all over Japan informing its people that "We are in possession of the most destructive explosive ever devised by man. A single one of our newly developed atomic bombs is actually the equivalent in explosive power to what 2,000 of our giant B-29s can carry on a single mission. This awful fact is one for you to ponder and we solemnly assure you it is grimly accurate. We have just begun to to use this weapon against your homeland. If you still have any doubt, make inquiry as to what happened to Hiroshima when just one atomic bomb fell on that city." Meanwhile, Tibbets's bomber group was simply waiting for the weather to clear in order to drop its next bomb, the plutonium weapon nicknamed "Fat Man" (right) that was destined for the city of Nagasaki.

Alzeimer's Disease or just a poor Memroy?

Alzheimer's Disease Fact Sheet



Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest tasks. In most people with AD, symptoms first appear after age 60.

AD is the most common cause of dementia among older people. Dementia is the loss of cognitive functioning—thinking, remembering, and reasoning—to such an extent that it interferes with a person’s daily life and activities. According to recent estimates, as many as 2.4 to 4.5 million Americans are living with AD.

AD is named after Dr. Alois Alzheimer. In 1906, Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness. Her symptoms included memory loss, language problems, and unpredictable behavior. After she died, he examined her brain and found many abnormal clumps (now called amyloid plaques) and tangled bundles of fibers (now called neurofibrillary tangles). Plaques and tangles in the brain are two of the main features of AD. The third is the loss of connections between nerve cells (neurons) in the brain.

Changes in the Brain in AD

Although we still don’t know what starts the AD process, we do know that damage to the brain begins as many as 10 to 20 years before any problems are evident. Tangles begin to develop deep in the brain, in an area called the entorhinal cortex, and plaques form in other areas. As more and more plaques and tangles form in particular brain areas, healthy neurons begin to work less efficiently. Then, they lose their ability to function and communicate with each other, and eventually they die. This damaging process spreads to a nearby structure, called the hippocampus, which is essential in forming memories. As the death of neurons increases, affected brain regions begin to shrink. By the final stage of AD, damage is widespread and brain tissue has shrunk significantly.

Very Early Signs and Symptoms

Memory problems are one of the first signs of AD. Some people with memory problems have a condition called amnestic mild cognitive impairment (MCI). People with this condition have more memory problems than normal for people their age, but their symptoms are not as severe as those with AD. More people with MCI, compared with those without MCI, go on to develop AD.

Other changes may also signal the very early stages of AD. For example, recent research has found links between some movement difficulties and MCI. Researchers also have seen links between some problems with the sense of smell and cognitive problems. Brain imaging and biomarker studies of people with MCI and those with a family history of AD are beginning to detect early changes in the brain like those seen in AD. These findings will need to be confirmed by other studies but appear promising. Such findings offer hope that some day, we may have tools that could help detect AD early, track the course of the disease, and monitor response to treatments.


Mild AD

As AD progresses, memory loss continues and changes in other cognitive abilities appear. Problems can include getting lost, trouble handling money and paying bills, repeating questions, taking longer to complete normal daily tasks, poor judgment, and mood and personality changes. People often are first diagnosed in this stage.

Moderate AD

In this stage, damage occurs in areas of the brain that control language, reasoning, sensory processing, and conscious thought. Memory loss and confusion increase, and people begin to have problems recognizing family and friends. They may be unable to learn new things, carry out tasks that involve multiple steps (such as getting dressed), or cope with new situations. They may have hallucinations, delusions, and paranoia, and may behave impulsively.

Severe AD

By the final stage, plaques and tangles have spread throughout the brain and brain tissue has shrunk significantly. People with severe AD cannot communicate and are completely dependent on others for their care. Near the end, the person may be in bed most or all of the time as the body shuts down.

What Causes AD

Scientists don’t yet fully understand what causes AD, but it is clear that it develops because of a complex series of events that take place in the brain over a long period of time. It is likely that the causes include genetic, environmental, and lifestyle factors. Because people differ in their genetic make-up and lifestyle, the importance of these factors for preventing or delaying AD differs from person to person.

The Basics of AD

Scientists are conducting studies to learn more about plaques, tangles, and other features of AD. They can now visualize plaques by imaging the brains of living individuals. They are also exploring the very earliest steps in the disease process. Findings from these studies will help them understand the causes of AD.

One of the great mysteries of AD is why it largely strikes older adults. Research on how the brain changes normally with age is shedding light on this question. For example, scientists are learning how age-related changes in the brain may harm neurons and contribute to AD damage. These age-related changes include inflammation and the production of unstable molecules called free radicals.

Genetics

In a very few families, people develop AD in their 30s, 40s, and 50s. These people have a mutation, or permanent change, in one of three genes that they inherited from a parent. We know that these gene mutations cause AD in these “early-onset” familial cases.

However, most people with AD have “late-onset” AD, which usually develops after age 60. Many studies have linked a gene called APOE to late-onset AD. This gene has several forms. One of them, APOE ε4, increases a person’s risk of getting the disease. About 40 percent of all people who develop late-onset AD carry this gene. However, carrying the APOE ε4 form of the gene does not necessarily mean that a person will develop AD, and people carrying no APOE ε4 forms can also develop AD.

Lifestyle Factors

A nutritious diet, exercise, social engagement, and mentally stimulating pursuits can all help people stay healthy. New research suggests the possibility that these factors also might help to reduce the risk of cognitive decline and AD. Scientists are investigating associations between cognitive decline and heart disease, high blood pressure, diabetes, and obesity. Understanding these relationships and testing them in clinical trials will help us understand whether reducing risk factors for these diseases may help with AD as well.

How AD Is Diagnosed

AD can be definitively diagnosed only after death by linking clinical course with an examination of brain tissue and pathology in an autopsy. But doctors now have several methods and tools to help them determine fairly accurately whether a person who is having memory problems has “possible AD” (the symptoms may be due to another cause) or “probable AD” (no other cause for the symptoms can be found). To diagnose AD, doctors:

  • ask questions about the person’s overall health, past medical problems, ability to carry out daily activities, and changes in behavior and personality
  • conduct tests of memory, problem solving, attention, counting, and language
  • carry out medical tests, such as tests of blood, urine, or spinal fluid
  • perform brain scans, such as a computerized tomography (CT) scan or a magnetic resonance imaging (MRI) test

These tests may be repeated to give doctors information about how the person’s memory is changing over time.

Early diagnosis is beneficial for several reasons. Having an early diagnosis and starting treatment in the early stages of the disease can help preserve function for months to years, even though the underlying AD process cannot be changed. Having an early diagnosis also helps families plan for the future, make living arrangements, take care of financial and legal matters, and develop support networks.

In addition, an early diagnosis can provide greater opportunities for people to get involved in clinical trials. In a clinical trial, scientists test drugs or treatments to see which are most effective and for whom they work best. (See the box, below, for more information.)

How AD Is Treated

AD is a complex disease, and no single “magic bullet” is likely to prevent or cure it. That’s why current treatments focus on several different aspects, including helping people maintain mental function; managing behavioral symptoms; and slowing, delaying, or preventing AD.

Helping People with AD Maintain Mental Function

Four medications are approved by the U.S. Food and Drug Administration to treat AD. Donepezil (Aricept®), rivastigmine (Exelon®), and galantamine (Razadyne®) are used to treat mild to moderate AD (donepezil can be used for severe AD as well). Memantine (Namenda®) is used to treat moderate to severe AD. These drugs work by regulating neurotransmitters (the chemicals that transmit messages between neurons). They may help maintain thinking, memory, and speaking skills, and help with certain behavioral problems. However, these drugs don’t change the underlying disease process and may help only for a few months to a few years.

Managing Behavioral Symptoms

Common behavioral symptoms of AD include sleeplessness, agitation, wandering, anxiety, anger, and depression. Scientists are learning why these symptoms occur and are studying new treatments—drug and non-drug—to manage them. Treating behavioral symptoms often makes people with AD more comfortable and makes their care easier for caregivers.

Slowing, Delaying, or Preventing AD

AD research has developed to a point where scientists can look beyond treating symptoms to think about addressing the underlying disease process. In ongoing AD clinical trials, scientists are looking at many possible interventions, such as cardiovascular treatments, antioxidants, immunization therapy, cognitive training, and physical activity.

Supporting Families and Caregivers

Caring for a person with AD can have high physical, emotional, and financial costs. The demands of day-to-day care, changing family roles, and difficult decisions about placement in a care facility can be hard to handle. Researchers are learning a lot about AD caregiving, and studies are helping experts develop new ways to support caregivers.

Becoming well-informed about AD is one important long-term strategy. Programs that teach families about the various stages of AD and about flexible and practical strategies for dealing with difficult caregiving situations provide vital help to those who care for people with AD.

Developing good coping skills and a strong support network of family and friends also are important ways that caregivers can help themselves handle the stresses of caring for a loved one with AD. For example, staying physically active provides physical and emotional benefits. Some AD caregivers have found that participating in an AD support group is a critical lifeline. These support groups allow caregivers to find respite, express concerns, share experiences, get tips, and receive emotional comfort. The Alzheimer’s Association, Alzheimer’s Disease Centers, and many other organizations sponsor in-person and online AD support groups across the country. There are a growing number of groups for people in the early stage of AD and their families. Support networks can be especially valuable when caregivers face the difficult decision of whether and when to place a loved one in a nursing home.

Marfan Syndome: Tall is not always Gold

Marfan syndrome

is an autosomal dominant genetic disorder of the connective tissue characterized by disproportionately long limbs, long thin fingers, a typically tall stature, and a predisposition to cardiovascular abnormalities, specifically those affecting the heart valves and aorta. The disorder may also affect numerous other structures and organs — including the lungs, eyes, dural sac surrounding the spinal cord, and hard palate. It is named after Antoine Marfan, the French pediatrician

Symptoms

Three systems are predominantly affected.

Ocular:
upward lens dislocation
retinal detachment

Skeletal:
arachnodactyly
tall with disproportionately long legs and arms - the span of the arms is greater than the height
pectus excavatum
spinal abnormalities - spondylolisthesis, scoliosis
increased incidence of slipped upper femoral epiphysis
generalised joint laxity with predisposition to flat feet or dislocation of patella or shoulder

Cardiovascular
- affecting the aortic and mitral valves and the ascending aorta:
dilatation of the aorta may be noted at any age, beginning at the aortic valve and usually confined to the ascending aorta
aortic insufficiency may result from stretching of the aortic valve ring and a dissecting aneurysm of the aorta may be a terminal event. Rarely, it occurs during pregnancy
mitral insufficiency results from redundant cusps and chordae tendineae
other cardiac malformations have occasionally been reported
Mental development is normal.

The average lifespan of an affected individual is 40 to 50 years.



Skeletal system
The most readily visible signs are associated with the skeletal system. Many individuals with Marfan Syndrome grow to above average height. Some have long slender limbs with fingers and toes that are also abnormally long and slender (arachnodactyly). This long, slender body habitus and long, slender limbs are known as dolichostenomelia. An individual's arms may be disproportionately long, with thin, weak wrists. In addition to affecting height and limb proportions, Marfan syndrome can produce other skeletal signs. Abnormal curvature of the spine (scoliosis) is common, as is abnormal indentation (pectus excavatum) or protrusion (pectus carinatum) of the sternum. Other signs include abnormal joint flexibility, a high palate, malocclusions, flat feet, stooped shoulders, unexplained stretch marks on the skin and thin wrists. Some people with Marfan have speech disorders resulting from symptomatic high palates and small jaws.


Eyes
Marfan syndrome can also seriously affect the eyes and vision. Nearsightedness and astigmatism are common, but farsightedness can also result. Periodic eye exams can lead to an ophthalmologist or optometrist discovering dislocation, or subluxation, of the crystalline lens in one or both eyes (ectopia lentis) by carefully observing these structures using a slit-lamp biomicroscope. This can be differentiated from the similar condition homocystinuria, where the dislocation is inferonasal; in Marfan's the dislocation is superotemporal. Sometimes eye problems appear only after the weakening of connective tissue has caused detachment of the retina.Early onset glaucoma can be another complication.


Cardiovascular system
The most serious conditions associated with Marfan syndrome involve the cardiovascular system. Undue fatigue, shortness of breath, heart palpitations, racing heartbeats, or pain in the left chest, back, shoulder, or arm, can bring a person into the doctor's office. Cold arms, hands and feet can also be seriously linked to marfan syndrome because of a loss of blood circulation. A heart murmur heard on a stethoscope, an abnormal reading on an electrocardiogram, or symptoms of angina can lead a doctor to order an echocardiogram. This can reveal signs of leakage or prolapse of the mitral or aortic valves that control the flow of blood through the heart. (See mitral valve prolapse.) However, the major sign that would lead a doctor to consider an underlying condition is a dilated aorta or an aortic aneurysm. Sometimes, no heart problems are apparent until the weakening of the connective tissue in the ascending aorta causes an aortic aneurysm or even aortic dissection.



Lungs
Marfan syndrome is a risk factor for spontaneous pneumothorax. In spontaneous unilateral pneumothorax, air escapes from a lung and occupies the pleural space between the chest wall and a lung. The lung becomes partially compressed or collapsed. This can cause pain, shortness of breath, cyanosis, and, if not treated, death. Marfan syndrome has also been associated with sleep apnea and idiopathic obstructive lung disease.


Central nervous system
Another condition that can reduce the quality of life for an individual, though not life-threatening, is dural ectasia, the weakening of the connective tissue of the dural sac, the membrane that encases the spinal cord. Dural ectasia can be present for a long time without producing any noticeable symptoms. Symptoms that can occur are lower back pain, leg pain, abdominal pain, other neurological symptoms in the lower extremities, or headaches. Such symptoms usually diminish when the individual lies flat on his or her back. These types of symptoms might lead a doctor to order an X-ray of the lower spine. Dural ectasia is usually not visible on an X-ray in the early phases. A worsening of symptoms and the lack of finding any other cause should eventually lead a doctor to order an upright MRI of the lower spine. Dural ectasia that has progressed to the point of causing these symptoms would appear in an upright MRI image as a dilated pouch that is wearing away at the lumbar vertebrae. Other spinal issues associated with Marfan include degenerative disk disease and spinal cysts.

Ascites_ Most common causes

ASCITES
Most common Ascites causes (90% of cases)
Cirrhosis (Cirrhotic Ascites)
Cancer (Malignant Ascites)
Congestive Heart Failure
Mycobacterium tuberculosis
Causes by locationPeritoneal sourceTuberculosisBacterial, fungal or parasitic diseaseCancer (Malignant Ascites)
Vasculitis
Whipple's Disease
Familial Mediterranean fever
Endometriosis
Starch peritonitis
Extra-peritoneal sourceCirrhosis (Cirrhotic Ascites)
Congestive Heart Failure
Budd-Chiari Syndrome
Hypoalbuminemia
Nephrotic Syndrome
Protein-losing enteropathy
Malnutrition
Myxedema
Ovarian disease (e.g. Meigs' Syndrome)
Pancreatic disease
Chylous Ascites

Kaposi Sarcoma : Horror of AIDS


Definition of Kaposi's Sarcoma

Kaposi's sarcoma (KS) is a disease in which cancer cells are found in the tissues under the skin or mucous membranes that line the mouth, nose, and anus.
KS causes red or purple patches (lesions) on the skin and/or mucous membranes and spreads to other organs in the body, such as the lungs, liver, or intestinal tract.



Description of Kaposi's Sarcoma

consists of characteristic skin lesions that range from flat to raised purple plaques. These tumors have a rich network of small blood vessels, and red blood cells moving slowly through these channels lose their oxygen, changing from red to blue. The mixture of red and blue cells gives the KS lesion a characteristic purple color.
There are several forms of KS, based on cause rather than appearance. The "classic" Kaposi's sarcoma, found mainly in Mediterranean males and mid-European Jews, has always been rare. In the 1950s a large number of cases were found in Africa, and the incidence has dramatically increased since then. KS was later found to be a common result of an alteration of body immunity.


There are two circumstances under which this alteration takes place.

The first is when depression of the immune system is part of some treatment, for example in kidney or other organ transplants. To prevent the foreign organ from being rejected, powerful drugs are given to shut down the immune system.
The second circumstance is associated with Acquired Immune Deficiency Syndrome (AIDS).
Types Of Tumors
KS tumors are divided into three groups, based on appearance, with much overlap.
Nodular lesions are of varying size and thickness. They are purple and will at times have a halo of brown or yellow pigment around them.
Infiltrating lesions may be quite large, may be raised, or grow downward beneath the skin.
Lymphatic lesions can mimic other causes of swollen lymph nodes and may require a biopsy to rule out infection.
Under the microscope, all three types of KS appear similar. But three sub-types have been identified, all of which are treated much the same. The spindle cell variety is the slowest growing, the anaplastic is the most aggressive, and the mixed cell has a somewhat intermediate growth rate.


Causes and Risk Factors of Kaposi's Sarcoma

The epidemic KS, occurring as a disease that accompanies AIDS, is thought to have a cause - the virus named HIV (Human Immunodeficiency Virus). If given a blood test for HIV, nearly all patients with epidemic KS will show evidence of being infected.
Various ideas have been advanced to explain how this virus causes KS. One theory is that it causes a normal cell to become malignant either directly or by initiating a chain of events. Various agents that may be involved in such a change have been identified.
Yet another idea has to do with the body's T cells, some of which hunt for malignant cells that have developed spontaneously and kill them off before they can become cancers. The T cell is known to be infected with the virus and cannot kill the malignant cells.

Symptoms of Kaposi's Sarcoma

There are no general symptoms of early KS. In the epidemic form, KS may be the first sign of AIDS, or, the first lesion may follow an illness of months or years. During this time, the patient may have had non-specific symptoms such as fever, weight loss and sweating. Possibly there were other illnesses, such as lymphoma or tuberculosis, before the first KS lesion developed.
Once the disease occurs, symptoms relate to the site of involvement. Early and more advanced skin lesions are usually only mildly uncomfortable, although painful ulcers may occur.
Lesions in the gastrointestinal tract are very common but rarely cause significant symptoms. Early lesions in the lung have no symptoms either, but severe lung involvement produces a profound air hunger.

Treatment of Kaposi's Sarcoma

KS is not considered curable. Neither surgical removal of the first-detected lesion nor obtaining a complete remission of multiple sites with chemotherapy or other techniques results in cure. Long-term survival does occur both with or without treatment, however.
Survival in classic KS is usually years and sometimes decades. Some patients with AIDS-related KS are still alive after 10 years, though most survive only a few years and treatment decisions are usually aimed at palliation.
All forms of KS are sensitive to
radiation therapy. Radiation is especially useful for lesions that are cosmetically disturbing, painful, involve the mouth extensively, block lymphatics, bleed, or protrude from the skin. Response rates are quite high and treatment is well tolerated.
Chemotherapy can be used in treatment but there is concern that aggressive treatment might further depress
the immune system. The disease does respond to chemotherapy, both with single agents and combinations of drugs.
KS is one of the few tumors that responds to local injections of chemotherapy. Many anticancer drugs cause intense local damage if they are accidentally injected into tissue. This undesirable effect has been used in a positive way to treat skin lesions.
Biological therapy involves immunologic treatment of KS primarily with the interferons, mainly alpha. Other agents, especially interleukin-2 are being studied.

Diabetes: Our Problem

Type 1 Diabetes
--------------------------------------------------------------------------------
Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. In type 1 diabetes, the body does not produce insulin. Insulin is a hormone that is needed to convert sugar (glucose), starches and other food into energy needed for daily life.

Finding out you have diabetes is scary. But don't panic. Type 1 diabetes is serious, but people with diabetes can live long, healthy, happy lives.
Conditions & TreatmentArm yourself with information about conditions associated with type 1 diabetes, and how to prevent them. Conditions associated with type 1 diabetes include hyperglycemia, hypoglycemia, ketoacidosis and celiac disease. You will also find helpful information about insulin, choosing blood glucose meters, various diagnostic tests including the A1c test, managing and checking your blood glucose, kidney and islet transplantations, and tips on what to expect from your health care provider.
Further Reading . . .A Field Guide to Type 1 Diabetes gives checklists of what you need, what to do in different situations, and what kinds of provisions you need.
For more books on healthy living, click here ComplicationsHaving type 1 diabetes increases your risk for many serious complications. Some complications of type 1 diabetes include: heart disease (cardiovascular disease), blindness (retinopathy), nerve damage (neuropathy), and kidney damage (nephropathy). Learn more about these complications and how to cope with them.
Recently DiagnosedYou've just been diagnosed with diabetes. Chances are you have a million questions running through your head. To help you answer those questions, and take the first steps toward better diabetes care, visit the Recently Diagnosed area for people who have just been diagnosed with diabetes, or those needing basic information.
Your Body's Well BeingMake it a priority to take good care of your body. The time you spend now on eye care, foot care and skin care, as well as your heart health and oral health, could delay or prevent the onset of dangerous type 1 diabetes complications later in life. Plus, some of the best things you can do for your body are to stop smoking, and reduce the amount of alcohol you drink.
Common ConcernsThis section addresses various areas to help you live with type 1 diabetes. What do you do when you're sick? What do you do when you travel? Can you get a flu shot with diabetes? How do you cope with having type 1 diabetes? Are you being discriminated against because you have diabetes? You'll find answers to these questions, and more in this section.
Ask the PharmacistThe American Diabetes Association and Rite Aid "Ask the Pharmacist" area is where you can ask a pharmacist a question to help you manage your diabetes. Rite Aid and the ADA have partnered to allow you to access to Rite Aid's Drug Information Center from our Web site.
Women and DiabetesLearn how to ensure your own health and well-being.
Health Information For MenLearn how to ensure your own health and well-being.

Type 2 Diabetes
--------------------------------------------------------------------------------
Type 2 diabetes is the most common form of diabetes. In type 2 diabetes, either the body does not produce enough insulin or the cells ignore the insulin. Insulin is necessary for the body to be able to use sugar. Sugar is the basic fuel for the cells in the body, and insulin takes the sugar from the blood into the cells. When glucose builds up in the blood instead of going into cells, it can cause two problems:
Right away, your cells may be starved for energy. Over time, high blood glucose levels may hurt your eyes, kidneys, nerves or heart. Finding out you have diabetes is scary. But don't panic. Type 2 diabetes is serious, but people with diabetes can live long, healthy, happy lives.
While diabetes occurs in people of all ages and races, some groups have a higher risk for developing type 2 diabetes than others. Type 2 diabetes is more common in African Americans, Latinos, Native Americans, and Asian Americans/Pacific Islanders, as well as the aged population.
Further Reading . . .A Field Guide to Type 2 Diabetes is an excellent book for the patient or family member.
For more books on healthy living, click here Conditions & TreatmentArm yourself with information about conditions associated with type 2 diabetes, and how to prevent them. Conditions associated with type 2 diabetes include hyperglycemia and hypoglycemia. You will also find helpful information about insulin, oral medications, various diagnostic tests including the A1c test, managing and checking your blood glucose, and tips on what to expect from your health care provider.
ComplicationsHaving type 2 diabetes increases your risk for many serious complications. Some complications of type 2 diabetes include: heart disease (cardiovascular disease), blindness (retinopathy), nerve damage (neuropathy), and kidney damage (nephropathy). Learn more about these complications and how to cope with them.
Diabetes Learning Center for the Recently DiagnosedYou've just been diagnosed with diabetes. Chances are you have a million questions running through your head. To help you answer those questions, and take the first steps toward better diabetes care, visit the Diabetes Learning Center -- an area for people who are newly diagnosed with diabetes, or those needing basic information.
Your Body's Well BeingMake it a priority to take good care of your body. The time you spend now on eye care, foot care and skin care, as well as your heart health and oral health, could delay or prevent the onset of dangerous type 2 diabetes complications later in life. Plus, some of the best things you can do for your body are to stop smoking, and reduce the amount of alcohol you drink.
Common ConcernsThis section addresses various areas to help you live with type 2 diabetes. What do you do when you're sick? What do you do when you travel? Can you get a flu shot with diabetes? How do you cope with having type 2 diabetes? Are you being discriminated against because you have diabetes? You'll find answers to these questions, and more in this section.
Ask the PharmacistThe American Diabetes Association and Rite Aid "Ask the Pharmacist" area is where you can ask a pharmacist a question to help you manage your diabetes. Rite Aid and the ADA have partnered to allow you to access to Rite Aid's Drug Information Center from our Web site.
Women and DiabetesLearn how to ensure your own health and well-being.
Health Information For MenLearn how to ensure your own health and well-being.

How to Prevent Pre-Diabetes
--------------------------------------------------------------------------------
Pre-diabetes is a serious medical condition that can be treated. The good news is that the recently completed Diabetes Prevention Program study conclusively showed that people with pre-diabetes can prevent the development of type 2 diabetes by making changes in their diet and increasing their level of physical activity. They may even be able to return their blood glucose levels to the normal range.
While the DPP also showed that some medications may delay the development of diabetes, diet and exercise worked better. Just 30 minutes a day of moderate physical activity, coupled with a 5-10% reduction in body weight, produced a 58% reduction in diabetes.
The American Diabetes Association is developing materials that will help people understand their risks for pre-diabetes and what they can do to halt the progression to diabetes and even to, "turn back the clock" In the meantime, ADA has a wealth of resources for people with diabetes or at risk for diabetes that can be of use to people interested in pre-diabetes.
Nutrition
Making Healthy Food Choices
ADA's statement for health professionals on nutrition
The American Diabetes Association bookstore has award-winning books on nutrition, recipes, weight loss, meal planning and more.
Exercise
Tips on how to include a healthy amount of physical activity into your daily routine:
Exercise and Diabetes
ADA's statement for health professionals on exercise
You can get fit, reduce your risk for type 2 diabetes, and support the American Diabetes Association by participating in America's Walk for Diabetes.
Tools
Small Steps. Big Rewards. Prevent type 2 diabetes.The National Diabetes Education Program has designed a national awareness campaign to target people at risk for type 2 diabetes. The campaign will create awareness that type 2 diabetes can be prevented through modest lifestyle changes and losing about 5 to 7 percent of body weight.

Face Lift


Short Scar Face Lift
Short scar face lift, also known as minimal access cranial suspension lift (MACS), is a great alternative for people who want the benefits of a traditional face lift but with less recovery time and scarring. Short scar face lift is a very popular procedure at our St. Louis-area office.
The procedure addresses the areas of the face that show the most visible signs of age. Unlike traditional face lift where an incision is made along the length of the hairline and around the ear, during short scar face lift a short incision is made in front of the ear and along the hairline. The skin is then separated from the muscle and fat, the muscles are tightened and the skin is pulled back. Short scar face lift is becoming an increasingly popular option for our St. Louis-area patients.
This procedure can be performed under local or general anesthesia and can be performed in conjunction with other procedures to improve results. During a consultation, Dr. Jeffrey Copeland will discuss all of the potential risks and benefits of the procedure.
If you are interested in short scar face lift, contact our cosmetic surgery office in St. Peters today.

Change : A rule Dr. Manish Pd. Sah




Change:A way of Life

Things change
thoughts change
people change
Times change
Friends change
Seasons change
Colors change
All Keep On Changing
Because Change Is Unchangeable
Dr. Manish

Eyes as u see ( med literature)


Each and every one has it in a pair. But nobody is sure if every of them percieve an object to be the same.Take it this way- if I see an object to be red you can not be sure a third person also percieves it as red. I mean he maybe perceiving it as blue but still saying it to be red as per his learnt habit since childhood. So the Biggest problem of the globe today is about belief. A belief which is created in ones mind as the influence of his/her environment.
As you Say:If little knowledge is dangerous then, show me a single man who has as much as to be out of danger.
Rabindra Nayak

Eyes-Nayak

EYES AS U SEE

Each and every one has it in a pair. But nobody is sure if every of them percieve an object to be the same.Take it this way- if I see an object to be red you can not be sure a third person also percieves it as red. I mean he maybe perceiving it as blue but still saying it to be red as per his learnt habit since childhood. So the Biggest problem of the globe today is about belief. A belief which is created in ones mind as the influence of his/her environment.

Rabindra Nayak

















As you Say:If little knowledge is dangerous then, show me a single man who has as much as to be out of danger.

SEARCH THIS BLOG FOR