Kaposi Sarcoma : Horror of AIDS

Definition of Kaposi's Sarcoma

Kaposi's sarcoma (KS) is a disease in which cancer cells are found in the tissues under the skin or mucous membranes that line the mouth, nose, and anus.
KS causes red or purple patches (lesions) on the skin and/or mucous membranes and spreads to other organs in the body, such as the lungs, liver, or intestinal tract.

Description of Kaposi's Sarcoma

consists of characteristic skin lesions that range from flat to raised purple plaques. These tumors have a rich network of small blood vessels, and red blood cells moving slowly through these channels lose their oxygen, changing from red to blue. The mixture of red and blue cells gives the KS lesion a characteristic purple color.
There are several forms of KS, based on cause rather than appearance. The "classic" Kaposi's sarcoma, found mainly in Mediterranean males and mid-European Jews, has always been rare. In the 1950s a large number of cases were found in Africa, and the incidence has dramatically increased since then. KS was later found to be a common result of an alteration of body immunity.

There are two circumstances under which this alteration takes place.

The first is when depression of the immune system is part of some treatment, for example in kidney or other organ transplants. To prevent the foreign organ from being rejected, powerful drugs are given to shut down the immune system.
The second circumstance is associated with Acquired Immune Deficiency Syndrome (AIDS).
Types Of Tumors
KS tumors are divided into three groups, based on appearance, with much overlap.
Nodular lesions are of varying size and thickness. They are purple and will at times have a halo of brown or yellow pigment around them.
Infiltrating lesions may be quite large, may be raised, or grow downward beneath the skin.
Lymphatic lesions can mimic other causes of swollen lymph nodes and may require a biopsy to rule out infection.
Under the microscope, all three types of KS appear similar. But three sub-types have been identified, all of which are treated much the same. The spindle cell variety is the slowest growing, the anaplastic is the most aggressive, and the mixed cell has a somewhat intermediate growth rate.

Causes and Risk Factors of Kaposi's Sarcoma

The epidemic KS, occurring as a disease that accompanies AIDS, is thought to have a cause - the virus named HIV (Human Immunodeficiency Virus). If given a blood test for HIV, nearly all patients with epidemic KS will show evidence of being infected.
Various ideas have been advanced to explain how this virus causes KS. One theory is that it causes a normal cell to become malignant either directly or by initiating a chain of events. Various agents that may be involved in such a change have been identified.
Yet another idea has to do with the body's T cells, some of which hunt for malignant cells that have developed spontaneously and kill them off before they can become cancers. The T cell is known to be infected with the virus and cannot kill the malignant cells.

Symptoms of Kaposi's Sarcoma

There are no general symptoms of early KS. In the epidemic form, KS may be the first sign of AIDS, or, the first lesion may follow an illness of months or years. During this time, the patient may have had non-specific symptoms such as fever, weight loss and sweating. Possibly there were other illnesses, such as lymphoma or tuberculosis, before the first KS lesion developed.
Once the disease occurs, symptoms relate to the site of involvement. Early and more advanced skin lesions are usually only mildly uncomfortable, although painful ulcers may occur.
Lesions in the gastrointestinal tract are very common but rarely cause significant symptoms. Early lesions in the lung have no symptoms either, but severe lung involvement produces a profound air hunger.

Treatment of Kaposi's Sarcoma

KS is not considered curable. Neither surgical removal of the first-detected lesion nor obtaining a complete remission of multiple sites with chemotherapy or other techniques results in cure. Long-term survival does occur both with or without treatment, however.
Survival in classic KS is usually years and sometimes decades. Some patients with AIDS-related KS are still alive after 10 years, though most survive only a few years and treatment decisions are usually aimed at palliation.
All forms of KS are sensitive to radiation therapy. Radiation is especially useful for lesions that are cosmetically disturbing, painful, involve the mouth extensively, block lymphatics, bleed, or protrude from the skin. Response rates are quite high and treatment is well tolerated.
Chemotherapy can be used in treatment but there is concern that aggressive treatment might further depress the immune system. The disease does respond to chemotherapy, both with single agents and combinations of drugs.
KS is one of the few tumors that responds to local injections of chemotherapy. Many anticancer drugs cause intense local damage if they are accidentally injected into tissue. This undesirable effect has been used in a positive way to treat skin lesions.
Biological therapy involves immunologic treatment of KS primarily with the interferons, mainly alpha. Other agents, especially interleukin-2 are being studied.

Insurance : Need of health insurance for life

A Health insurance policy
is a contract between an insurance company and an individual. The
contract can be renewable annually or monthly. The type and amount of health care costs that will
be covered by the health plan are specified in advance, in the member contract or Evidence of
Coverage booklet. The individual policy-holder's payment obligations may take several forms[4]:

Premium: The amount the policy-holder pays to the health plan each month to purchase health
coverage.

Deductible: The amount that the policy-holder must pay out-of-pocket before the health plan pays
its share. For example, a policy-holder might have to pay a $500 deductible per year, before any of
their health care is covered by the health plan. It may take several doctor's visits or prescription
refills before the policy-holder reaches the deductible and the health plan starts to pay for care.

Copayment: The amount that the policy-holder must pay out of pocket before the health plan pays
for a particular visit or service. For example, a policy-holder might pay a $45 copayment for a
doctor's visit, or to obtain a prescription. A copayment must be paid each time a particular service
is obtained.

Coinsurance: Instead of paying a fixed amount up front (a copayment), the policy-holder must pay a percentage of the total cost. For example, the member might have to pay 20% of the cost of a
surgery, while the health plan pays the other %80. Because there is no upper limit on
coinsurance, the policy-holder can end up owing very little, or a significant amount, depending on
the actual costs of the services they obtain.

Exclusions: Not all services are covered. The policy-holder is generally expected to pay the full cost of non-covered services out of their own pocket. Coverage limits: Some health plans only pay for health care up to a certain dollar amount. The
policy-holder may be expected to pay any charges in excess of the health plan's maximum
payment for a specific service. In addition, some plans have annual or lifetime coverage
maximums. In these cases, the health plan will stop payment when they reach the benefit
maximum, and the policy-holder must pay all remaining costs. Out-of-pocket maximums: Similar to coverage limits, except that in this case, the member's payment obligation ends when they reach the out-of-pocket maximum, and the health plan pays all further covered costs. Out-of-pocket maximums can be limited to a specific benefit category (such as prescription drugs) or can apply to all coverage provided during a specific benefit year.

Prescription drug plans are a form of insurance offered through many employer benefit plans in
the U.S., where the patient pays a copayment and the prescription drug insurance pays the rest.
Some health care providers will agree to bill the insurance company if patients are willing to sign
an agreement that they will be responsible for the amount that the insurance company doesn't
pay, as the insurance company pays according to "reasonable" or "customary" charges, which
may be less than the provider's usual fee.
Health insurance companies also often have a network of providers who agree to accept the
reasonable and customary fee and waive the remainder. It will generally cost the patient less to
use an in-network provider.

Health Insurance companies are now offering Health Incentive accounts (HIA)[5], to reward users
for living healthy and making healthy choices, like stop smoking and/or losing weight, may get you
funds added into your Health Incentive Account, which may lower your out of pocket costs. The
health incentive accounts also carry over from year to year but once you leave the program you
lose those benefits in the HIA.
[edit]

Private: individually purchasedPolicies of health insurance obtained by individuals not otherwise covered under policies or programs elsewhere classified. Generally major medical, short term medical, and student policies. According to the U.S. Census Bureau, about 9% of Americans are covered under health insurance purchased directly.[14] The range of products available is similar to those provided through employers. Average premiums are generally somewhat lower than those for employer-sponsored coverage, but vary by age. Deductibles and other cost-sharing are also higher, on average, and the individual consumer pays the entire premium without benefit of an employer contribution.[21] Many states allow medical underwriting of applicants for individually purchased health insurance by insurance companies.
[edit] Private: long-term care insuranceLong-term care (LTC) insurance is growing in popularity in the U.S. Premiums have remained relatively stable in recent years. However, the coverage is quite expensive, especially when consumers wait until retirement age to purchase it. The average age of new purchasers was 61 in 2005, and has been dropping.

New types of medical plans in the U.S.One approach to addressing increasing premiums, dubbed "consumer driven health care," received a boost in 2003, when President George W. Bush signed into law the Medicare Prescription Drug, Improvement, and Modernization Act. The law created tax-deductible Health Savings Accounts (HSAs). An HSA is a private bank account which is un-taxed and only penalized if spent on non-medical items or services. It must be paired with a high-deductible insurance plan. HSAs enable mostly healthy people to pay less for insurance and bank money for their own health care expenses.[23] HSAs are one form of tax-preferrenced health care spending account. Others include Archer Medical Savings Accounts (MSAs), which have been superseded by the new HSAs (although existing MSAs are grandfathered), Flexible Spending Arrangments (FSAs) and Health Reimbursement Accounts (HRAs). FSAs and HRAs are typically used as part of an employee-benefit plan.[24]
Limited Medical Benefit Plans pay for routine care and do not pay for catastrophic care. As such, they do not provide equivalent financial security to a major medical plan. Annual benefit limits can be as low as $2,000. Lifetime maximums can be very low as well.

Mesothelioma, The curse of Asbestos

Mesothelioma is a cancer of the cells that make up the lining around the outside of the lungs and inside of the ribs (pleura), or around the abdominal organs (peritoneum).


The only known cause of mesothelioma in the U.S. is previous exposure to asbestos fibers. Asbestos manufacturers knew about the hazards of asbestos seventy years ago - but they kept this knowledge to themselves. The first warnings to workers exposed to asbestos were given in the mid-1960s, and they were terribly inadequate. Even today, workers are not always told they are working around asbestos and are at risk for asbestos disease.


Do these:

Seek out the best and most up-to-date information.
Seek out the best medical care.
Early screening for mesothelioma diagnosis.
Stay in close contact with your doctor.
Consider whether or not you want to bring a lawsuit because of this asbestos-related injury.
Remember that resources are available to you through community and medical support groups, asbestos victims' organizations, your place of worship, as well as your family and friends.
Do you want more information about mesothelioma?
Please explore our website or contact us to request additional information

Pleural Mesothelioma
Pleural mesothelioma is of two kinds: (1) diffuse and malignant (cancerous), and (2) localized and benign (non-cancerous.)

Benign mesotheliomas can often be removed surgically, are generally not life-threatening, and are not usually related to asbestos exposure. Malignant mesotheliomas, however, are very serious. Fortunately, they are rare - about two thousand people are diagnosed with mesothelioma in the U.S. each year.

The remainder of this section is about diffuse malignant pleural mesothelioma.

Pleural mesothelioma is a cancer of the cells that make up the pleura or lining around the outside of the lungs and inside of the ribs. Its only known cause in the U.S. is previous exposure to asbestos fibers, including chrysotile, amosite or crocidolite. This exposure is likely to have happened twenty or more years before the disease becomes evident, since it takes many years for the disease to "incubate." It is the most common type of mesothelioma, accounting for about 75% of all cases.

Mesothelioma is sometimes diagnosed by coincidence, before there are any symptoms. For instance, tumors have been discovered through routine chest x-rays. However, when symptoms occur, they may include shortness of breath, weakness, weight loss, loss of appetite, chest pains, lower back pains, persistent coughing, difficulty in swallowing, alone or in combination. An initial medical examination often shows a pleural effusion, which means an accumulation of fluid in the pleural space - the area between the lungs and the chest wall.

The first step in detecting pleural mesothelioma is, typically, a chest x-ray or CT scan. This is often followed by a bronchoscopy, using a viewing scope to look inside the lungs.

The actual diagnosis usually requires obtaining a piece of tissue through a biopsy. This could be a needle biopsy, an open biopsy, or through a tube with a camera (thoracoscopy or chest scope.) If an abnormality is seen through the camera then a tissue sample can be taken at the same time, using the same tube. This is a hospital procedure that requires anesthesia, but is not usually painful. The tissue sample is tested by a pathologist.

Fluid build-up from the pleural effusion can generally be seen on a chest x-ray and heard during a physical examination, but a firm diagnosis of mesothelioma can only be made through a biopsy and pathological testing. This is important because there are also benign pleural effusions and other tumors that have a similar appearance to mesothelioma. Diagnosing mesothelioma can be quite difficult; it requires special lab stains, and much experience in understanding them.

The spread of the tumor over the pleura causes pleural thickening. This can reduce the flexibility of the pleura and encase the lungs in an increasingly restrictive girdle. With the lungs restricted, they get smaller and less functional, and breathing becomes more difficult. At first a person with mesothelioma may be breathless only when he or she exercises, but as lung function drops, he or she can become short of breath even while resting.

The tumor spreads by direct invasion of surrounding tissue. As it spreads inward it can compress the lungs. As the tumor spreads outward it can invade the chest wall and ribs, and this can be extremely painful.

Current medical science does not know exactly how and why, at a cellular level, asbestos fibers cause mesothelial cells to become abnormal (malignant or cancerous.) Thus it is not known whether only one fiber causes the tumor or whether it takes many fibers. It seems that asbestos fibers in the pleura can start a tumor as well as promote its growth; the tumor does not depend on any other processes for its development.

There is as yet no known cure for malignant mesothelioma. The prognosis depends on various factors, including the size and stage of the tumor, the extent of the tumor, the cell type, and whether or not the tumor responds to treatment. The Firm has represented many clients who lived for five to ten years after diagnosis, most of them in good health for a majority of those years. Some mesothelioma victims succumb within a few months; the average survival time is about a year.

The treatment options for people with mesothelioma have improved significantly, especially for those whose cancer is diagnosed early and treated vigorously. Many people are treated with a combination of therapies, sometimes known as multimodal therapy.

Specific types of treatment include:

Chemotherapy and other drug-based therapies
Radiation therapy
Surgery and
Intra-operative photodynamic therapy.
There are also experimental treatments like gene therapy and immunotherapy, angiogenesis inhibitors, and clinical trials for various new treatments and combinations of treatments.

Treatments that reduce pain and improve lung function, are becoming more successful (although they cannot cure mesothelioma.) Pain control medications have become easier to administer. Debulking is a surgical process of removing a substantial part of the tumor and reducing the pleural thickening; this can provide significant relief. X-ray therapy has also been successfully used to control the tumor and the pain associated with it for a while.

Further Resources
More information about pleural mesothelioma and treatments:

Malignant Pleural Mesothelioma: Update, Current Management, and Newer Therapeutic Strategies, by M. Pistolesi, MD & J. Rusthoven, MD; Chest October 2004; 126(4):1318-1329
National Cancer Institute
University of Pennsylvania/OncoLink
American Cancer Society
Medicine Online
Froedtert Medical College - Thoracic oncology program offers a comprehensive range of treatment options, with special expertise in treament of mesothelioma.


Diagnosis for Malignant Mesothelioma Cancer: Screening
The National Cancer Institute's definition of screening for cancer is the examination or testing of people for early signs of certain type of cancer even though they have no symptons - this is the best way to achieve a diagnosis as early as possible. Early detection and diagnosis is particularly important for people with historical exposure to asbestos due to the latency period (up to 30 years) before which symptoms of malignant mesothelioma cancer may become apparent.

Early Signs of Mesothelioma Aid Diagnosis:

Recognizing early symptoms of malignant mesothelioma may aid in diagnosis. Symptoms include difficulty in breathing (dyspnea) and/or chest pains, fever, nausea or anemia; other signals are hoarseness, difficulty swallowing (dysphagia), or coughing up blood (hemoptysis). For many suffering from pleural mesothelioma, there may be pain in the chest or lower back. Those people with peritoneal mesothelioma may experience an expanding waist size or abdominal pain resulting from the growth of cancer cells in the abdomen.

Since many of these symptoms are also caused by less serious illnesses, it can be difficult to recognize asbestos-related diseases in the early stages. Due to this difficulty of early diagnosis of asbestos cancer and mesothelioma, the best way to determine your health risk is to consult a doctor for an initial examination, which may include a pulmonary function test (PFT) and x-rays.

Screening Methods to Identify Asbestos-Related Disease:

After a preliminary physical examination, the doctor may need to look inside your chest cavity with a thorascope for accurate diagnosis. During this thoracoscopy procedure, a cut will be made in your chest and a small piece of tissue (biopsy) may removed for examination. While you may feel some pressure, there is usually no pain.

Another special tool that may be used is the peritoneoscope, which allows for examination inside your abdomen. This instrument is inserted into an opening made in the abdomen, and a biopsy specimen may also be taken.

If the presence of fluid is indicated by either of these procedures, the doctor may drain it by inserting a needle into the affected area. Removal of chest fluid is called thoracentesis; removal of abdominal fluid is call paracentesis.

Other screening methods for diagnosis of asbestos-related disease include various imaging tests. In addition to X-rays, methods include magnetic resonance imaging (MRI) or positron emission tomography (PET). A more recent and promising screening method is the computed tomography (CT) scan.

Computed Tomagraphy / CT Scan: