Irrirtable Bowel Syndrome IBS : Short review and Rome II Criteria




Irritable bowel syndrome (IBS) is a term for a variety of diseases causing discomfort in the gastro-intestinal tract. Also called spastic colon, it is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any organic cause.


In some cases, the symptoms are relieved by bowel movements.Diarrhea or constipation may predominate, or they may alternate (classified as IBS-D, IBS-C or IBS-A, respectively). IBS may begin after an infection (post-infectious, IBS-PI) or a stressful life event or may begin at onset of maturity without any other medical indicators.

Differential Diagnosis


celiac disease, mild infections, parasitic infections like giardiasis, several inflammatory bowel diseases, functional chronic constipation, and chronic functional abdominal pain.


Symptoms
The primary symptoms of IBS are abdominal pain or discomfort in association with frequent diarrhea or constipation, a change in bowel habits. There may also be urgency for bowel movements, a feeling of incomplete evacuation (tenesmus), bloating or abdominal distention. People with IBS more commonly than others have gastroesophageal reflux, symptoms relating to the genitourinary system, psychological symptoms, fibromyalgia, chronic fatigue syndrome, headache and backache.


Rome Process for Diagnosing IBS
The cardinal requirement for the diagnosis of IBS is abdominal pain. The Rome II criteria is used to diagnose IBS after a careful examination of the patient's medical history and physical abdominal examination which looks for any 'red flag' symptoms. More recently, the Rome III criteria, incorporating some changes over the previous set of criteria, have been issued. The Rome II and III efforts have integrated pediatric contents to their set of criteria.

According to the Rome II committees and the Functional Brain Gut Research Group, IBS can be diagnosed based on at least 12 weeks, which need not be consecutive, of the preceding 12 months there was abdominal discomfort or pain that had two out of three of these features:

Relieved with defecation; and/or
Onset associated with a change in frequency of stool; and/or
Onset associated with a change in form (appearance) of stool.
Symptoms that cumulatively support the diagnosis of IBS:


Abnormal stool frequency (for research purposes, "abnormal" may be defined as greater than 3 bowel movements per day and less than 3 bowel movements per week);
Abnormal stool form (lumpy/hard or loose/watery stool);
Abnormal stool passage (straining, urgency, or feeling of incomplete evacuation);
Bloating or feeling of abdominal distention.
Supportive symptoms of IBS:

A) Fewer than three bowel movements a week
B) More than three bowel movements a day
C) Hard or lumpy stools
D) Loose (mushy) or watery stools
E) Straining during a bowel movement
F) Urgency (having to rush to have a bowel movement)
G) Feeling of incomplete bowel movement
H) Passing mucus (white material) during a bowel movement
I) Abdominal fullness, bloating, or swelling
Diarrhea-predominant: At least 1 of B, D, F and none of A, C, E; or at least 2 of B, D, F and one of A or E.
Constipation-predominant: At least 1 of A, C, E and none of B, D, F; or at least 2 of A, C, E and one of B, D, F.

Red flag symptoms which are not typical of IBS:

Pain that awakens/interferes with sleep
Diarrhea that awakens/interferes with sleep
Blood in the stool (visible or occult)
Weight loss
Fever
Abnormal physical examination

An update to these criteria was issued at the Rome III conference and published in May 2006.The validity of subtypes is called into question:



Management: Davidson

Specific Virus Families causing disease in animals and plants


  1. Adenovirus

  2. Afican Swine Fever Virus

  3. Animal Viruses

  4. Arbovirus

  5. Arenavirus
  6. Arterivirus
  7. Astrovirus
  8. Bacteriophage
  9. Baculovirus

  10. Bunyavirus

  11. Calicivirus

  12. Caulimovirus

  13. Coronavirus
  14. Filovirus

  15. Flavivirus

  16. Hepadnavirus

  17. Herpesvirus
  18. Myovirus

  19. Nodavirus

  20. Orthomyxovirus

  21. Paramyxovirus

  22. Papovavirus

  23. Parvovirus

  24. Phycodnavirus

  25. Picornavirus

  26. Poxvirus
  27. Reovirus

  28. Retrovirus

  29. Rhabdovirus

  30. Togavirus
  31. Viroids

Swine Flu : Who Are at Risk

Which groups are at greatest risk?

Some people are more at risk than others of serious illness if they catch swine flu. They will need to start taking antivirals as soon as they are confirmed with the illness. On occasion, doctors may advise some high risk patients to take antivirals before they have symptoms if someone close to them has swine flu.

The risk profile of the virus is still being studied but it is already known that certain groups of people are particularly vulnerable. These include:

  • Patients who have had drug treatment for asthma in the past three years
  • Pregnant women
  • People aged 65 years and older
  • Children under five years old
  • People with chronic lung disease
  • People with chronic heart disease
  • People with chronic kidney disease
  • People with chronic liver disease
  • People with chronic neurological disease
  • People with immunosuppression (whether caused by disease or treatment)
  • People with diabetes mellitus

Why are healthy people over 65 and children not a priority for the swine flu vaccine?

Healthy people aged over 65 appear to have some natural immunity to the swine flu virus. And while children are disproportionately affected by swine flu, the vast majority make a full recovery - therefore the experts do not advise that children (other than those in at-risk groups) should be vaccinated initially.

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